I live on the 22nd floor. I've never lived this way up. I spent almost my entire life on the second floor. I was briefly on the 4th, 7th, 8th and recently on the 9th, but 22nd is the highest I've ever been.
The first thing I noticed was how quiet it was. There is no street noise from the 22nd floor. Apart from the almost imperceptible muzak coming out of the 22nd floor landing and the elevator (which you can't hear at all with the A/C on) it is eerily quiet.
And I love quiet.